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Pediatric Demyelination (Smaller Patients) 3T

Siemens Healthineers – MR Gadopiclenol (VUEWAY®) Protocols

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Instructions And Patient Preparation

Instructions
Position the head in the head coil and immobilize with cushions
Give cushions under the legs for extra comfort
Connect the anterior portion of the head coil and secure it in place.
Sedation vs bundle and feed is the ordering provider’s decision
Common Indications
Demyelination Disease
Multiple Sclerosis
Position
Head First
Supine
Coil
Head Coil 20ch
Landmark
Center over the glabella
Patient Population
These protocols are intended for smaller patients and serve as starting points. If a smaller FOV is needed, the parameters are modified accordingly.

Contrast Agent Parameters

Contrast Agent Dose Injection Rate Dose Timing Method and Scan Delay
Gadopiclenol (VUEWAY) 0.1 mL/kg Hand injected Post-contrast series acquired after gadolinium administration

Imaging Parameters

Scan Description AAhead_scout SAG
MPRAGE
3D		 SAG
3D
T2
FLAIR		 AX
SWI		 AX
DWI		 COR
T2WI
(3mm)
DRB		 COR
T2
DIXON
ORBITS
(3mm)
DRB		 POST
SAG
MPRAGE
3D		 POST
AX
T1WI
FLAIR
DRB		 POST
AX
T2
FLAIR
DRB		 POST
COR
T1WI
FS
DIXON
ORBITS
(3mm)
DRB
    View Image View Image View Image View Image View Image View Image View Image View Image View Image View Image
Sequence Name fl tfl spcir swi_r epse tse tse tfl tir tir tse
Dimension 3D 3D 3D 3D 2D 2D 2D 3D 2D 2D 2D
Acceleration mode GRAPPA GRAPPA GRAPPA GRAPPA SMS GRAPPA GRAPPA GRAPPA GRAPPA GRAPPA GRAPPA
Total Factor ― ― 2 ― ― ― ― ― ― ― ―
Acceleration Factor PE 3 2 2 2 2 3 2 2 3 3 2
Acceleration Factor 3D 1 1 1 1 ― ― ― 1 ― ― ―
Reference Lines PE 24 64 24 24 30 26 31 64 27 52 27
Reference Scans Integrated GRE/Separate Integrated Integrated EPI/Separate Integrated Integrated GRE/Separate Integrated Integrated Integrated
Deep Resolve ― ― ― Off Off On On ― On On On

Scan Parameters

Scan Description AAhead_scout SAG
MPRAGE
3D		 SAG
3D
T2
FLAIR		 AX
SWI		 AX
DWI		 COR
T2WI
(3mm)
DRB		 COR
T2
DIXON
ORBITS
(3mm)
DRB		 POST
SAG
MPRAGE
3D		 POST
AX
T1WI
FLAIR
DRB		 POST
AX
T2
FLAIR
DRB		 POST
COR
T1WI
FS
DIXON
ORBITS
(3mm)
DRB
TR 3.15 ms 2500.0 ms 5000.0 ms 27.0 ms 3200.0 ms 4000.0 ms 3000.0 ms 2500.0 ms 2000.0 ms 9000.0 ms 600.0 ms
TE 1.37 ms 3.87 ms 382.00 ms 20.00 ms 87.00 ms 106.00 ms 84.00 ms 3.87 ms 9.00 ms 126.00 ms 9.50 ms
TI ― 1240 ms 1800 ms ― ― ― ― 1240 ms 900 ms 2500 ms ―
Flip Angle 8 deg 8 deg T2 Var 15 deg ― 160 deg 160 deg 8 deg 150 deg 150 deg 160 deg
Bandwidth 540 Hz/Px 170 Hz/Px 651 Hz/Px 120 Hz/Px 1540 Hz/Px 250 Hz/Px 383 Hz/Px 170 Hz/Px 260 Hz/Px 289 Hz/Px 630 Hz/Px
Turbo Factor ― 224 278 ― ― 17 17 224 5 21 3
Echo Spacing ― 9.06 ms 3.94 ms ― 0.94 ms 9.66 ms 10.50 ms 9.06 ms 9.02 ms 9.02 ms 9.48 ms
Echo Trains per Slice ― ― ― ― ― 11 16 ― 26 7 90
EPI Factor ― ― ― ― 112 ― ― ― ― ― ―
Gradient Mode Normal Normal Fast Normal Fast* Fast Fast Normal Fast Fast Fast
RF Pulse Type Fast Normal Normal Fast Normal Normal Normal Normal Normal Normal Normal
RF Spoiling On On ― On ― ― ― On ― ― ―
Asymmetric Echo Weak Off ― Off ― ― Off Off ― ― Off
Flow Compensation ― None None On ― None None None None None None
Reduce Motion Sens. ― ― ― ― ― On On ― On On On
Phase Correction ― ― ― ― External Automatic Automatic ― Automatic Automatic Automatic

Contrast & Magnetization

Scan Description AAhead_scout SAG
MPRAGE
3D		 SAG
3D
T2
FLAIR		 AX
SWI		 AX
DWI		 COR
T2WI
(3mm)
DRB		 COR
T2
DIXON
ORBITS
(3mm)
DRB		 POST
SAG
MPRAGE
3D		 POST
AX
T1WI
FLAIR
DRB		 POST
AX
T2
FLAIR
DRB		 POST
COR
T1WI
FS
DIXON
ORBITS
(3mm)
DRB
Fat-Water Contrast Standard Standard Fat Saturation Standard Fat Saturation Standard Dixon Standard Standard Fat Saturation Dixon
Fat Saturation ― ― Strong ― Strong ― Strong ― ― Strong Strong
Magn. Preparation ― Non-sel. IR Non-sel. T2-IR None None None None Non-sel. IR Slice-sel. IR Slice-sel. IR None
MTC ― ― Off Off Off Off Off ― Off Off Off
Dark Blood ― Off Off Off ― Off Off Off Off Off Off
Contrasts 1 1 ― 1 ― 1 1 1 1 1 1
Reconstruction Magnitude Magnitude Magnitude Magn./Phase Magnitude Magnitude Magnitude Magnitude Magnitude Magnitude Magnitude
Wrap-up Magn. ― ― None ― ― None None ― None None None

Acquisition Parameters

Scan Description AAhead_scout SAG
MPRAGE
3D		 SAG
3D
T2
FLAIR		 AX
SWI		 AX
DWI		 COR
T2WI
(3mm)
DRB		 COR
T2
DIXON
ORBITS
(3mm)
DRB		 POST
SAG
MPRAGE
3D		 POST
AX
T1WI
FLAIR
DRB		 POST
AX
T2
FLAIR
DRB		 POST
COR
T1WI
FS
DIXON
ORBITS
(3mm)
DRB
Base Resolution 160 224 256 256 112 400 256 224 320 320 256
Phase Resolution 100 % 100 % 100 % 96 % 100 % 85 % 80 % 100 % 70 % 70 % 80 %
Slice Resolution 69 % 100 % 100 % 100 % ― ― ― 100 % ― ― ―
Averages 1 1 1.0 1 ― 1 1 1 1 1 1
Concatenations 1 1 1 1 1 2 2 1 2 2 2
FoV Read 260 mm 200 mm 200 mm 180 mm 180 mm 180 mm 140 mm 200 mm 180 mm 180 mm 140 mm
FoV Phase 100.0 % 100.0 % 100.0 % 100.0 % 100.0 % 100.0 % 100.0 % 100.0 % 100.0 % 100.0 % 100.0 %
Phase Encoding Dir. A >> P A >> P A >> P R >> L A >> P R >> L R >> L A >> P R >> L R >> L R >> L
Phase Oversampling 0 % 0 % 0 % 0 % 0 % 50 % 150 % 0 % 50 % 50 % 150 %
Slice Oversampling 0.0 % 7.7 % 0.0 % 10.0 % ― ― ― 7.7 % ― ― ―
Phase Partial Fourier 6/8 Off Off 7/8 7/8 Off Off Off Off Off Off
Slice Partial Fourier 6/8 Off Off 7/8 ― ― ― Off ― ― ―
Interpolation ― On On Off On On On On On On On
Trajectory Cartesian ― ― ― ― ― Cartesian ― ― ― Cartesian
Multi-Slice Mode Sequential Single Shot ― Interleaved Interleaved Interleaved Interleaved Single Shot Interleaved Interleaved Interleaved

Scanning Range

Scan Description AAhead_scout SAG
MPRAGE
3D		 SAG
3D
T2
FLAIR		 AX
SWI		 AX
DWI		 COR
T2WI
(3mm)
DRB		 COR
T2
DIXON
ORBITS
(3mm)
DRB		 POST
SAG
MPRAGE
3D		 POST
AX
T1WI
FLAIR
DRB		 POST
AX
T2
FLAIR
DRB		 POST
COR
T1WI
FS
DIXON
ORBITS
(3mm)
DRB
Slice Thickness 1.6 mm 0.90 mm 0.78 mm 1.50 mm 4.0 mm 3.0 mm 3.0 mm 0.90 mm 4.0 mm 4.0 mm 3.0 mm
Slices 128 Slices
per Slab		 208 Slices
per Slab		 192 Slices
per Slab		 80 Slices
per Slab		 34 Slices 45 Slices 30 Slices 208 Slices
per Slab		 33 Slices 34 Slices 27 Slices
Distance Factor 20 % 50 % ― 20 % 10 % 10 % 10 % 50 % 10 % 10 % 10 %
Special Saturation ― ― None None None None None ― None None None
Raw Filter Off Off On Off Off Off Off Off Off Off Off
Elliptical Filter Off Off Off Off Off Off Off Off Off Off Off
Image Filter Off On Off Off ― Off Off On Off Off Off
Distortion Correction 3D 2D 2D 2D Off 2D 2D 2D 2D 2D 2D
Normalize Prescan Prescan Prescan Prescan Prescan Prescan Prescan Prescan Prescan Prescan Prescan
Noise Masking Off ― ― ― Off ― ― ― ― ― ―
Time of Acquisition 14 sec 4:52 min 8:12 min 4:11 min 3:20 min 1:38 min 3:20 min 4:52 min 1:50 min 2:26 min 3:39 min

Diffusion

Scan Description AAhead_scout SAG
MPRAGE
3D		 SAG
3D
T2
FLAIR		 AX
SWI		 AX
DWI		 COR
T2WI
(3mm)
DRB		 COR
T2
DIXON
ORBITS
(3mm)
DRB		 POST
SAG
MPRAGE
3D		 POST
AX
T1WI
FLAIR
DRB		 POST
AX
T2
FLAIR
DRB		 POST
COR
T1WI
FS
DIXON
ORBITS
(3mm)
DRB
Diffusion Mode ― ― ― ― MDDW ― ― ― ― ― ―
Diffusion Scheme ― ― ― ― Monopolar ― ― ― ― ― ―
Diff. Directions ― ― ― ― 6 ― ― ― ― ― ―
b-value 1 ― ― ― ― 0 s/mm² ― ― ― ― ― ―
b-value 2 ― ― ― ― 1000 s/mm² ― ― ― ― ― ―
Averages b-value 1 ― ― ― ― 1 ― ― ― ― ― ―
Averages b-value 2 ― ― ― ― 3 ― ― ― ― ― ―
Diff. Weightings ― ― ― ― 3 ― ― ― ― ― ―
Diff. Weighted Images ― ― ― ― Off ― ― ― ― ― ―
Trace Weighted Images ― ― ― ― On ― ― ― ― ― ―
ADC Maps ― ― ― ― On ― ― ― ― ― ―
Exponential ADC Maps ― ― ― ― Off ― ― ― ― ― ―
FA Maps ― ― ― ― On ― ― ― ― ― ―
Calculated Image ― ― ― ― Off ― ― ― ― ― ―